Patent ductus arteriosus pathophysiology

Jump to: navigation, search

Patent Ductus Arteriosus Microchapters


Patient Information




Historical Perspective



Differentiating Patent Ductus Arteriosus from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis


History and Symptoms

Physical Examination

Laboratory Findings


Chest X Ray




Other Imaging Findings


Medical Therapy

Preterm Infants
Term and Older Children


Primary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Patent ductus arteriosus pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Patent ductus arteriosus pathophysiology

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Patent ductus arteriosus pathophysiology

CDC on Patent ductus arteriosus pathophysiology

Patent ductus arteriosus pathophysiology in the news

Blogs on Patent ductus arteriosus pathophysiology

Directions to Hospitals Treating Type page name here

Risk calculators and risk factors for Patent ductus arteriosus pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Priyamvada Singh, M.B.B.S. [2], Cafer Zorkun, M.D., Ph.D. [3], Assistant Editor-In-Chief: Kristin Feeney, B.S. [4]


The pathophysiological consequences depend on the size of the defect and the pulmonary vascular resistance.[1]


Small-Sized PDA

Medium-Sized PDA

  • Qp/Qs 1.5 to 2.0 yet small enough to offer some resistance to flow.
  • PA systolic to systemic pressures are < 0.5
  • Unusual for this group to have markedly increased PVR.
  • Due to increased return to the left heart, there is volume overload of the left atrium (LA) and the left ventricle (LV).

Large PDA

  • Defect does not restrict flow.
  • There is pulmonary hypertension at near systemic pressures (PA systolic/systolic pressure is >0.5).
  • Because of the physiologic decrease in the PVR over the first three months of life there is a large left-to-right shunt with Qp/Qs > 2.
  • The large volume overload of the left ventricle may result in LV failure.
  • There is pulmonary hypertension.
  • There may be two courses:
    • A decrease in the relative size of the ductus compared with other cardiovascular structures. This results in a medium-sized defect compared with the course expected for a medium-sized defect.
    • The development of severe pulmonary vascular obstructive disease, can occur at any time from age 3 until early adulthood. The left-to-right shunt converts to a right-to-left shunt with cyanosis and disappearance of the continuous murmur.

Gross Pathology

Shown below is the pictoral image of pathophysiology of patent ductus arteriosus

Pictoral illustration of patent ductus arteriosus

Shown below is the image of pathophysiology of patent ductus arteriosus in the cross-section of the heart

Pathophysiology of PDA



  1. Giuliani et al, Cardiology: Fundamentals and Practice, Second Edition, Mosby Year Book, Boston, 1991, pp. 1653-1663.