Patent ductus arteriosus natural history, complications, and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Priyamvada Singh, M.B.B.S. [2], Cafer Zorkun, M.D., Ph.D. [3], Assistant Editor-In-Chief: Kristin Feeney, B.S. [4]

Overview

The natural history of unoperated patients of patent ductus arteriosus depends on the amount of left to right shunting. The left to right shunting in turn depends on the size of ductus and the difference in resistance between the left and right side of heart. PDA can cause complications such as heart failure, infective endocarditis, rhythm disturbance, pulmonary hypertension and Eisenmenger syndrome.

Natural History

Small PDA

  • May remain asymptomatic
  • Rarely can increase the risk of endarteritis

Moderate PDA

  • Left sided heart dysfunction
  • Rhythm disturbances like atrial fibrillation as a result of left sided dysfunction

Large PDA

Complications

Heart Failure

Infective Endocarditis

Rhythm Disturbance

Pulmonary Hypertension

Eisenmenger Syndrome

Prognosis

Prognosis of patent ductus arteriosus varies widely. It depends on:

  • The size of patent ductus arteriosus
  • Whether the patient has been treated with closure medicines.
  • Whether surgery has been done.
  • Whether the patient with complications or not, such as heart failure, problems with lung development, or infective endocarditis.

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